Non Serious Adverse Drug Reactions Report
Start Date:2016-08-19 End Date:2016-08-20
Study :EMR700623-541	Investigator :Fei Gong		Country of Investigator :China	SiteNo:C01
Subject No :C01-0001	Subject Initials :TTW	DOB :05/13/1988	Sex:Female	Race:Asian	Height:157cm	Weight:3050g
First administration date of batch :			Batch number :
Study Drug	Start Date		Dose	Change in Dose
Gonal-f New Pen Stimulation Treatment	05/16/2015		112.5
Adverse Event	Start Date	End Date	Time related to study treatment	Causality to study drug	Severity
OHSS	06/06/2015	06/15/2015		Related	Moderate
Causality Factors		Action Taken with Study Treatment	Other action taken	Outcome	AE Special Interest	AE dose limiting toxicity
None(Othervalue:)		Not applicable	Concomitant procedure**	Resolved
Event Description:Nausea, vomiting, yellow urine with less volume, chest pelvic effusion,ascites puncture 10-Jun-2015,2200ml;ascites puncture 15-Jun-2015,2900ml;
Subject received concomitant medications:
Does the subject have any relevant past or present medical conditions:Yes
Condition				Start Date	Related to study condition	Ongoing
Bilateral fallopian tube obstruction				04/11/2014	Not on treatment/medication	Ongoing

				19-AUG-16
				Fei Gong/EMR700623-541/C01-0001
				Page 1 of41

Non Serious Adverse Drug Reactions Report
Start Date:2016-08-19 End Date:2016-08-20
Study :EMR700623-541	Investigator :Fei Gong		Country of Investigator :China	SiteNo:C01
Subject No :C01-0068	Subject Initials :X-S	DOB :04/16/1989	Sex:Female	Race:Asian	Height:160cm	Weight:2500g
First administration date of batch :			Batch number :
Study Drug	Start Date		Dose	Change in Dose
Gonal-f New Pen Stimulation Treatment	06/27/2015		150
Adverse Event	Start Date	End Date	Time related to study treatment	Causality to study drug	Severity
OHSS	07/23/2015	08/04/2015		Related	Severe
Causality Factors		Action Taken with Study Treatment	Other action taken	Outcome	AE Special Interest	AE dose limiting toxicity
None(Othervalue:)		Not applicable	Concomitant procedure**	Resolved
Event Description:Abdominal distension, Nausea, yellow urine with less volume, chest pelvic effusion，Ascites puncture 23Jul2015,1000ml; 27Jul2015,2100ml; 30Jul2015,2500ml; 04Aug2015,2000ml；
Subject received concomitant medications:
Does the subject have any relevant past or present medical conditions:Yes
Condition				Start Date	Related to study condition	Ongoing
The left Hydrosalpinx and adhesions,less patency.Right fallopian tube partially blocked				03/22/2014	Not on treatment/medication	Ongoing
right fallopian tube resection because of Ectopic pregnancy				UK-Oct-2011	Not on treatment/medication

				19-AUG-16
				Fei Gong/EMR700623-541/C01-0068
				Page 2 of41

Non Serious Adverse Drug Reactions Report
Start Date:2016-08-19 End Date:2016-08-20
Study :EMR700623-541	Investigator :Fei Gong		Country of Investigator :China	SiteNo:C01
Subject No :C01-0158	Subject Initials :T-Y	DOB :06/17/1983	Sex:Female	Race:Asian	Height:163cm	Weight:3300g
First administration date of batch :			Batch number :
Study Drug	Start Date		Dose	Change in Dose
Gonal-f New Pen Stimulation Treatment	09/16/2015		112.5
Adverse Event	Start Date	End Date	Time related to study treatment	Causality to study drug	Severity
OHSS	10/12/2015	10/12/2015		Related	Moderate
Causality Factors		Action Taken with Study Treatment	Other action taken	Outcome	AE Special Interest	AE dose limiting toxicity
None(Othervalue:)		Not applicable	Concomitant procedure**	Resolved
Event Description:Abdominal distension, Nausea, yellow urine with less volume, chest pelvic effusion,ascites puncture 12-Oct-2015,2500ml
Subject received concomitant medications:
Does the subject have any relevant past or present medical conditions:Yes
Condition				Start Date	Related to study condition	Ongoing
right fallopian tube is less patency,left fallopian tube is obstruction				06/04/2015	Not on treatment/medication	Ongoing
Endometrial polyps hyperplasia				08/24/2015	Not on treatment/medication	Ongoing

				19-AUG-16
				Fei Gong/EMR700623-541/C01-0158
				Page 3 of41

Non Serious Adverse Drug Reactions Report
Start Date:2016-08-19 End Date:2016-08-20
Study :EMR700623-541	Investigator :NA		Country of Investigator :China	SiteNo:C02
Subject No :C02-0002	Subject Initials :LLL	DOB :02/12/1987	Sex:Female	Race:Asian	Height:158cm	Weight:50.0kg
First administration date of batch :			Batch number :
Study Drug	Start Date		Dose	Change in Dose
Gonal-f New Pen Stimulation Treatment	05/08/2015		150
Adverse Event	Start Date	End Date	Time related to study treatment	Causality to study drug	Severity
OHSS	05/25/2015	06/03/2015		Related	Moderate
Causality Factors		Action Taken with Study Treatment	Other action taken	Outcome	AE Special Interest	AE dose limiting toxicity
None(Othervalue:)		Not applicable	Led to study termination	Resolved
Event Description:Moderate OHSS patients, improved canceled after embryo transfer.
Subject received concomitant medications:
Does the subject have any relevant past or present medical conditions:Yes
Condition				Start Date	Related to study condition	Ongoing
salpingemphrxis,lalace peritoneoscope				Uk-Jul-2014	Not on treatment/medication

				19-AUG-16
				NA/EMR700623-541/C02-0002
				Page 4 of41

Non Serious Adverse Drug Reactions Report
Start Date:2016-08-19 End Date:2016-08-20
Study :EMR700623-541	Investigator :NA		Country of Investigator :China	SiteNo:C02
Subject No :C02-0118	Subject Initials :MLF	DOB :08/03/1984	Sex:Female	Race:Asian	Height:160cm	Weight:55.0kg
First administration date of batch :			Batch number :
Study Drug	Start Date		Dose	Change in Dose
Gonal-f New Pen Stimulation Treatment	05/21/2015		150
Adverse Event	Start Date	End Date	Time related to study treatment	Causality to study drug	Severity
OHSS	06/07/2015	06/12/2015		Related	Moderate
Causality Factors		Action Taken with Study Treatment	Other action taken	Outcome	AE Special Interest	AE dose limiting toxicity
None(Othervalue:)		Not applicable	Led to study termination	Resolved
Event Description:Moderate OHSS occurs canceled embryo transfer, OHSS improvement
Subject received concomitant medications:
Does the subject have any relevant past or present medical conditions:Yes
Condition				Start Date	Related to study condition	Ongoing
HSG: bilateral tubal obstruction				Uk-Unk-2007	Not on treatment/medication
Laparoscopic pelvic sticky points, bilateral ovarian drilling				Uk-Unk-2007	Not on treatment/medication
Cervical biopsy showing inflammation				Uk-Unk-2015	Not on treatment/medication

				19-AUG-16
				NA/EMR700623-541/C02-0118
				Page 5 of41

Non Serious Adverse Drug Reactions Report
Start Date:2016-08-19 End Date:2016-08-20
Study :EMR700623-541	Investigator :NA		Country of Investigator :China	SiteNo:C04
Subject No :C04-0087	Subject Initials :HZD	DOB :08/04/1983	Sex:Female	Race:Asian	Height:161cm	Weight:60kg
First administration date of batch :			Batch number :
Study Drug	Start Date		Dose	Change in Dose
Gonal-f New Pen Stimulation Treatment	06/26/2015		225
Adverse Event	Start Date	End Date	Time related to study treatment	Causality to study drug	Severity
OHSS	07/07/2015	07/21/2015		Related	Mild
Causality Factors		Action Taken with Study Treatment	Other action taken	Outcome	AE Special Interest	AE dose limiting toxicity
None(Othervalue:)		Dose reduced	None	Resolved
Event Description:none
Subject received concomitant medications:
Does the subject have any relevant past or present medical conditions:Yes
Condition				Start Date	Related to study condition	Ongoing
spontaneous abortion				01/05/2010	Not on treatment/medication
spontaneous abortion				05/18/2012	Not on treatment/medication

				19-AUG-16
				NA/EMR700623-541/C04-0087
				Page 6 of41

Non Serious Adverse Drug Reactions Report
Start Date:2016-08-19 End Date:2016-08-20
Study :EMR700623-541	Investigator :NA		Country of Investigator :China	SiteNo:C04
Subject No :C04-0171	Subject Initials :SHL	DOB :08/17/1987	Sex:Female	Race:Asian	Height:154cm	Weight:40kg
First administration date of batch :			Batch number :
Study Drug	Start Date		Dose	Change in Dose
Gonal-f New Pen Stimulation Treatment	09/29/2015		300
Adverse Event	Start Date	End Date	Time related to study treatment	Causality to study drug	Severity
OHSS	09/30/2015	10/09/2015		Related	Mild
Causality Factors		Action Taken with Study Treatment	Other action taken	Outcome	AE Special Interest	AE dose limiting toxicity
None(Othervalue:)		Dose reduced	None	Resolved
Event Description:none
Subject received concomitant medications:
Does the subject have any relevant past or present medical conditions:No
Condition				Start Date	Related to study condition	Ongoing

				19-AUG-16
				NA/EMR700623-541/C04-0171
				Page 7 of41

Non Serious Adverse Drug Reactions Report
Start Date:2016-08-19 End Date:2016-08-20
Study :EMR700623-541	Investigator :Ying Zhong		Country of Investigator :China	SiteNo:C05
Subject No :C05-0001	Subject Initials :XFZ	DOB :01/21/1988	Sex:Female	Race:Asian	Height:159cm	Weight:50kg
First administration date of batch :			Batch number :
Study Drug	Start Date		Dose	Change in Dose
Gonal-f New Pen Stimulation Treatment	08/01/2015		225
Adverse Event	Start Date	End Date	Time related to study treatment	Causality to study drug	Severity
OHSS	08/16/2015	08/18/2015		Related	Severe
Causality Factors		Action Taken with Study Treatment	Other action taken	Outcome	AE Special Interest	AE dose limiting toxicity
None(Othervalue:)		Not applicable	None	Resolved
Event Description:Hydroxyethyl Starch 130/0.4 and Sodium Chloride Injection 500ml，ivgtt bid calcium gluconate injection 10ml+dextrose injection 500ml ivgtt qd
Subject received concomitant medications:
Does the subject have any relevant past or present medical conditions:Yes
Condition				Start Date	Related to study condition	Ongoing
oophorocystectomy				UK-Jul-2013	Not on treatment/medication
salpingoplasty				UK-Feb-2014	Not on treatment/medication
salpingitis after previous tubal occlusion				UK-Feb-2014	Not on treatment/medication	Ongoing

				19-AUG-16
				Ying Zhong/EMR700623-541/C05-0001
				Page 8 of41

Non Serious Adverse Drug Reactions Report
Start Date:2016-08-19 End Date:2016-08-20
Study :EMR700623-541	Investigator :Ying Zhong		Country of Investigator :China	SiteNo:C05
Subject No :C05-0010	Subject Initials :Q-Z	DOB :01/31/1990	Sex:Female	Race:Asian	Height:159cm	Weight:45kg
First administration date of batch :			Batch number :
Study Drug	Start Date		Dose	Change in Dose
Gonal-f New Pen Stimulation Treatment	08/02/2015		225
Adverse Event	Start Date	End Date	Time related to study treatment	Causality to study drug	Severity
OHSS	08/17/2015	08/24/2015		Related	Moderate
Causality Factors		Action Taken with Study Treatment	Other action taken	Outcome	AE Special Interest	AE dose limiting toxicity
Disease under study,Protocol procedure,Concomitant medication**(Othervalue:)		Dose not changed	Led to study termination	Resolved
Event Description:abdominal distention;nausea Drug：Hydroxyethyl Starch 130/0.4 and Sodium Chloride Injection 500ml，ivgtt bid calcium gluconate injection 10ml+dextrose injection 500ml ivgtt qd 17-Aug-2015 / 27-Aug-2015
Subject received concomitant medications:
Does the subject have any relevant past or present medical conditions:No
Condition				Start Date	Related to study condition	Ongoing

				19-AUG-16
				Ying Zhong/EMR700623-541/C05-0010
				Page 9 of41

Non Serious Adverse Drug Reactions Report
Start Date:2016-08-19 End Date:2016-08-20
Study :EMR700623-541	Investigator :Ying Zhong		Country of Investigator :China	SiteNo:C05
Subject No :C05-0013	Subject Initials :L-L	DOB :06/12/1986	Sex:Female	Race:Asian	Height:159cm	Weight:54.5kg
First administration date of batch :			Batch number :
Study Drug	Start Date		Dose	Change in Dose
Gonal-f New Pen Stimulation Treatment	08/02/2015		150
Adverse Event	Start Date	End Date	Time related to study treatment	Causality to study drug	Severity
OHSS	08/18/2015	08/20/2015		Related	Moderate
Causality Factors		Action Taken with Study Treatment	Other action taken	Outcome	AE Special Interest	AE dose limiting toxicity
Disease under study,Protocol procedure,Concomitant medication**(Othervalue:)		Dose not changed	Led to study termination	Resolved
Event Description:abdominal distention;nausea ,ascites,Drug：Hydroxyethyl Starch 130/0.4 and Sodium Chloride Injection 500ml，ivgtt bid calcium gluconate injection 10ml+dextrose injection 500ml ivgtt qd 18-Aug-2015 / 20-Aug-2015
Subject received concomitant medications:
Does the subject have any relevant past or present medical conditions:Yes
Condition				Start Date	Related to study condition	Ongoing
ampullary pregnancy				UK-Unk-2010	Not on treatment/medication
ampullary pregnancy				UK-Unk-2012	Not on treatment/medication
ampullary pregnancy				UK-Unk-2013	Not on treatment/medication
salpingocatheterism				UK-Unk-2013	Not on treatment/medication

				19-AUG-16
				Ying Zhong/EMR700623-541/C05-0013
				Page 10 of41

Non Serious Adverse Drug Reactions Report
Start Date:2016-08-19 End Date:2016-08-20
Study :EMR700623-541	Investigator :Ying Zhong		Country of Investigator :China	SiteNo:C05
Subject No :C05-0021	Subject Initials :FYZ	DOB :08/28/1990	Sex:Female	Race:Asian	Height:150cm	Weight:45kg
First administration date of batch :			Batch number :
Study Drug	Start Date		Dose	Change in Dose
Gonal-f New Pen Stimulation Treatment	08/04/2015		225
Adverse Event	Start Date	End Date	Time related to study treatment	Causality to study drug	Severity
OHSS	08/19/2015	08/21/2015		Related	Mild
Causality Factors		Action Taken with Study Treatment	Other action taken	Outcome	AE Special Interest	AE dose limiting toxicity
Protocol procedure,Concomitant medication(Othervalue:)		Not applicable	None	Resolved
Event Description:abdominal distention;Drug：Hydroxyethyl Starch 130/0.4 and Sodium Chloride Injection 500ml，ivgtt bid calcium gluconate injection 10ml+dextrose injection 500ml ivgtt qd 19-Aug-2015 / 21-Aug-2015
Subject received concomitant medications:
Does the subject have any relevant past or present medical conditions:Yes
Condition				Start Date	Related to study condition	Ongoing
salpingocatheterism				UK-Unk-2012	Not on treatment/medication

				19-AUG-16
				Ying Zhong/EMR700623-541/C05-0021
				Page 11 of41

Non Serious Adverse Drug Reactions Report
Start Date:2016-08-19 End Date:2016-08-20
Study :EMR700623-541	Investigator :Ying Zhong		Country of Investigator :China	SiteNo:C05
Subject No :C05-0041	Subject Initials :W-Y	DOB :07/03/1981	Sex:Female	Race:Asian	Height:153cm	Weight:55kg
First administration date of batch :			Batch number :
Study Drug	Start Date		Dose	Change in Dose
Gonal-f New Pen Stimulation Treatment	08/08/2015		150
Adverse Event	Start Date	End Date	Time related to study treatment	Causality to study drug	Severity
OHSS	08/23/2015	08/25/2015		Related	Mild
Causality Factors		Action Taken with Study Treatment	Other action taken	Outcome	AE Special Interest	AE dose limiting toxicity
Protocol procedure,Concomitant medication(Othervalue:)		Dose not changed	Led to study termination	Resolved
Event Description:abdominal distention;Drug：Hydroxyethyl Starch 130/0.4 and Sodium Chloride Injection 500ml，ivgtt bid calcium gluconate injection 10ml+dextrose injection 500ml ivgtt qd 21-Aug-2015 / 25-Aug-2015
Subject received concomitant medications:
Does the subject have any relevant past or present medical conditions:No
Condition				Start Date	Related to study condition	Ongoing

				19-AUG-16
				Ying Zhong/EMR700623-541/C05-0041
				Page 12 of41

Non Serious Adverse Drug Reactions Report
Start Date:2016-08-19 End Date:2016-08-20
Study :EMR700623-541	Investigator :Ying Zhong		Country of Investigator :China	SiteNo:C05
Subject No :C05-0056	Subject Initials :X-P	DOB :06/14/1983	Sex:Female	Race:Asian	Height:158cm	Weight:46kg
First administration date of batch :			Batch number :
Study Drug	Start Date		Dose	Change in Dose
Gonal-f New Pen Stimulation Treatment	08/13/2015		150
Adverse Event	Start Date	End Date	Time related to study treatment	Causality to study drug	Severity
OHSS	08/27/2015	08/29/2015		Related	Mild
Causality Factors		Action Taken with Study Treatment	Other action taken	Outcome	AE Special Interest	AE dose limiting toxicity
Protocol procedure,Concomitant medication(Othervalue:)		Not applicable	Led to study termination	Resolved
Event Description:abdominal distention;nausea ;ascites;Drug：Hydroxyethyl Starch 130/0.4 and Sodium Chloride Injection 500ml，ivgtt bid calcium gluconate injection 10ml+dextrose injection 500ml ivgtt qd 17-Aug-2015 / 27-Aug-2015
Subject received concomitant medications:
Does the subject have any relevant past or present medical conditions:No
Condition				Start Date	Related to study condition	Ongoing

				19-AUG-16
				Ying Zhong/EMR700623-541/C05-0056
				Page 13 of41

Non Serious Adverse Drug Reactions Report
Start Date:2016-08-19 End Date:2016-08-20
Study :EMR700623-541	Investigator :Ying Zhong		Country of Investigator :China	SiteNo:C05
Subject No :C05-0068	Subject Initials :YPL	DOB :12/07/1985	Sex:Female	Race:Asian	Height:160cm	Weight:50kg
First administration date of batch :			Batch number :
Study Drug	Start Date		Dose	Change in Dose
Gonal-f New Pen Stimulation Treatment	08/15/2015		225
Adverse Event	Start Date	End Date	Time related to study treatment	Causality to study drug	Severity
OHSS	08/27/2015	08/29/2015		Related	Moderate
Causality Factors		Action Taken with Study Treatment	Other action taken	Outcome	AE Special Interest	AE dose limiting toxicity
Protocol procedure,Concomitant medication(Othervalue:)		Dose not changed	Led to study termination	Resolved
Event Description:abdominal distention;nausea ;ascites;Drug：Hydroxyethyl Starch 130/0.4 and Sodium Chloride Injection 500ml，ivgtt bid calcium gluconate injection 10ml+dextrose injection 500ml ivgtt qd 17-Aug-2015 / 27-Aug-2015
Subject received concomitant medications:
Does the subject have any relevant past or present medical conditions:Yes
Condition				Start Date	Related to study condition	Ongoing
Fallopian tube repair anaplasty				UK-Unk-2010	Not on treatment/medication

				19-AUG-16
				Ying Zhong/EMR700623-541/C05-0068
				Page 14 of41

Non Serious Adverse Drug Reactions Report
Start Date:2016-08-19 End Date:2016-08-20
Study :EMR700623-541	Investigator :Ying Zhong		Country of Investigator :China	SiteNo:C05
Subject No :C05-0117	Subject Initials :Y-L	DOB :04/16/1982	Sex:Female	Race:Asian	Height:165cm	Weight:48kg
First administration date of batch :			Batch number :
Study Drug	Start Date		Dose	Change in Dose
Gonal-f New Pen Stimulation Treatment	08/23/2015		225
Adverse Event	Start Date	End Date	Time related to study treatment	Causality to study drug	Severity
OHSS	09/08/2015	09/10/2015		Related	Mild
Causality Factors		Action Taken with Study Treatment	Other action taken	Outcome	AE Special Interest	AE dose limiting toxicity
Protocol procedure,Concomitant medication(Othervalue:)		Dose reduced	Led to study termination	Resolved
Event Description:abdominal distention;ascites;Drug：Hydroxyethyl Starch 130/0.4 and Sodium Chloride Injection 500ml，ivgtt bid calcium gluconate injection 10ml+dextrose injection 500ml ivgtt qd 19-Aug-2015 / 21-Aug-2015
Subject received concomitant medications:
Does the subject have any relevant past or present medical conditions:No
Condition				Start Date	Related to study condition	Ongoing

				19-AUG-16
				Ying Zhong/EMR700623-541/C05-0117
				Page 15 of41

Non Serious Adverse Drug Reactions Report
Start Date:2016-08-19 End Date:2016-08-20
Study :EMR700623-541	Investigator :Ying Zhong		Country of Investigator :China	SiteNo:C05
Subject No :C05-0141	Subject Initials :XHZ	DOB :04/14/1987	Sex:Female	Race:Asian	Height:158cm	Weight:48kg
First administration date of batch :			Batch number :
Study Drug	Start Date		Dose	Change in Dose
Gonal-f New Pen Stimulation Treatment	08/29/2015		150
Adverse Event	Start Date	End Date	Time related to study treatment	Causality to study drug	Severity
OHSS	09/12/2015	09/14/2015		Related	Moderate
Causality Factors		Action Taken with Study Treatment	Other action taken	Outcome	AE Special Interest	AE dose limiting toxicity
Protocol procedure,Concomitant medication(Othervalue:)		Dose not changed	Led to study termination	Resolved
Event Description:abdominal distention;nausea ;ascites;Drug：Hydroxyethyl Starch 130/0.4 and Sodium Chloride Injection 500ml，ivgtt bid calcium gluconate injection 10ml+dextrose injection 500ml ivgtt qd 17-Aug-2015 / 27-Aug-2015
Subject received concomitant medications:
Does the subject have any relevant past or present medical conditions:Yes
Condition				Start Date	Related to study condition	Ongoing
Fallopian tube repair anaplasty				UK-Unk-2009	Not on treatment/medication

				19-AUG-16
				Ying Zhong/EMR700623-541/C05-0141
				Page 16 of41

Non Serious Adverse Drug Reactions Report
Start Date:2016-08-19 End Date:2016-08-20
Study :EMR700623-541	Investigator :NA		Country of Investigator :Korea	SiteNo:K01
Subject No :k01-0059	Subject Initials :LKH	DOB :08/05/1981	Sex:Female	Race:Asian	Height:153cm	Weight:74g
First administration date of batch :			Batch number :
Study Drug	Start Date		Dose	Change in Dose
Gonal-f New Pen Stimulation Treatment	06/02/2015		225
Adverse Event	Start Date	End Date	Time related to study treatment	Causality to study drug	Severity
OHSS	06/13/2015	07/02/2015		Related	Mild
Causality Factors		Action Taken with Study Treatment	Other action taken	Outcome	AE Special Interest	AE dose limiting toxicity
None(Othervalue:)		Dose not changed	None	Resolved
Event Description:
Subject received concomitant medications:
Does the subject have any relevant past or present medical conditions:No
Condition				Start Date	Related to study condition	Ongoing

				19-AUG-16
				NA/EMR700623-541/k01-0059
				Page 17 of41

Non Serious Adverse Drug Reactions Report
Start Date:2016-08-19 End Date:2016-08-20
Study :EMR700623-541	Investigator :NA		Country of Investigator :Korea	SiteNo:K01
Subject No :k01-035	Subject Initials :PSS	DOB :01/19/1983	Sex:Female	Race:Asian	Height:161cm	Weight:56g
First administration date of batch :			Batch number :
Study Drug	Start Date		Dose	Change in Dose
Gonal-f New Pen Stimulation Treatment	03/11/2015		225
Adverse Event	Start Date	End Date	Time related to study treatment	Causality to study drug	Severity
OHSS	03/23/2015	04/21/2015		Related	Mild
Causality Factors		Action Taken with Study Treatment	Other action taken	Outcome	AE Special Interest	AE dose limiting toxicity
None(Othervalue:)		Dose not changed	None	Resolved
Event Description: no addtional data
Subject received concomitant medications:
Does the subject have any relevant past or present medical conditions:No
Condition				Start Date	Related to study condition	Ongoing

				19-AUG-16
				NA/EMR700623-541/k01-035
				Page 18 of41

Non Serious Adverse Drug Reactions Report
Start Date:2016-08-19 End Date:2016-08-20
Study :EMR700623-541	Investigator :NA		Country of Investigator :Korea	SiteNo:K01
Subject No :k01-036	Subject Initials :JSY	DOB :07/28/1981	Sex:Female	Race:Asian	Height:162cm	Weight:54g
First administration date of batch :			Batch number :
Study Drug	Start Date		Dose	Change in Dose
Gonal-f New Pen Stimulation Treatment	03/13/2015		225
Adverse Event	Start Date	End Date	Time related to study treatment	Causality to study drug	Severity
OHSS	03/24/2015	04/07/2015		Related	Moderate
Causality Factors		Action Taken with Study Treatment	Other action taken	Outcome	AE Special Interest	AE dose limiting toxicity
None(Othervalue:)		Dose not changed	Concomitant medication **	Resolved
Event Description:
Subject received concomitant medications:
Does the subject have any relevant past or present medical conditions:No
Condition				Start Date	Related to study condition	Ongoing

				19-AUG-16
				NA/EMR700623-541/k01-036
				Page 19 of41

Non Serious Adverse Drug Reactions Report
Start Date:2016-08-19 End Date:2016-08-20
Study :EMR700623-541	Investigator :NA		Country of Investigator :Korea	SiteNo:K01
Subject No :k01-040	Subject Initials :LBH	DOB :03/05/1985	Sex:Female	Race:Asian	Height:164cm	Weight:61g
First administration date of batch :			Batch number :
Study Drug	Start Date		Dose	Change in Dose
Gonal-f New Pen Stimulation Treatment	04/06/2015		225
Adverse Event	Start Date	End Date	Time related to study treatment	Causality to study drug	Severity
OHSS	04/15/2015	04/30/2015		Related	Mild
Causality Factors		Action Taken with Study Treatment	Other action taken	Outcome	AE Special Interest	AE dose limiting toxicity
None(Othervalue:)		Dose not changed	None	Resolved
Event Description:
Subject received concomitant medications:
Does the subject have any relevant past or present medical conditions:No
Condition				Start Date	Related to study condition	Ongoing

				19-AUG-16
				NA/EMR700623-541/k01-040
				Page 20 of41

Non Serious Adverse Drug Reactions Report
Start Date:2016-08-19 End Date:2016-08-20
Study :EMR700623-541	Investigator :NA		Country of Investigator :Korea	SiteNo:K01
Subject No :k01-049	Subject Initials :PGR	DOB :02/20/1983	Sex:Female	Race:Asian	Height:168cm	Weight:62g
First administration date of batch :			Batch number :
Study Drug	Start Date		Dose	Change in Dose
Gonal-f New Pen Stimulation Treatment	05/02/2015		300
Adverse Event	Start Date	End Date	Time related to study treatment	Causality to study drug	Severity
OHSS	05/13/2015	05/29/2015		Related	Mild
Causality Factors		Action Taken with Study Treatment	Other action taken	Outcome	AE Special Interest	AE dose limiting toxicity
None(Othervalue:)		Not applicable	Concomitant medication **	Resolved
Event Description:albumin treatment and resloved
Subject received concomitant medications:
Does the subject have any relevant past or present medical conditions:Yes
Condition				Start Date	Related to study condition	Ongoing
laparoscopic ovary cystectomy				UK-UNK-2004	Not on treatment/medication

				19-AUG-16
				NA/EMR700623-541/k01-049
				Page 21 of41

Non Serious Adverse Drug Reactions Report
Start Date:2016-08-19 End Date:2016-08-20
Study :EMR700623-541	Investigator :NA		Country of Investigator :Korea	SiteNo:K01
Subject No :k01-050	Subject Initials :KHG	DOB :04/22/1984	Sex:Female	Race:Asian	Height:150cm	Weight:46g
First administration date of batch :			Batch number :
Study Drug	Start Date		Dose	Change in Dose
Gonal-f New Pen Stimulation Treatment	05/03/2015		300
Adverse Event	Start Date	End Date	Time related to study treatment	Causality to study drug	Severity
OHSS	05/14/2015	05/29/2015		Related	Mild
Causality Factors		Action Taken with Study Treatment	Other action taken	Outcome	AE Special Interest	AE dose limiting toxicity
None(Othervalue:)		Dose not changed	Led to study termination	Resolved
Event Description:
Subject received concomitant medications:
Does the subject have any relevant past or present medical conditions:Yes
Condition				Start Date	Related to study condition	Ongoing
ovary cystectomy				UK-Jan-2014	Not on treatment/medication

				19-AUG-16
				NA/EMR700623-541/k01-050
				Page 22 of41